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What is Botulinum Toxin A treatment in aesthetics?

What are the FDA-approved indications of Botulinum Toxin A in aesthetics?

In what type of facial wrinkles is Botulinum Toxin A effective (Dynamic/static)?

What are the ingredients in BONT A?

What is the advantage of the Thin Film Formulation technique?

What is the diluent for reconstitution of the Wocktox vial?

What are the storage conditions for the Wocktox vial?

What is the spreadibility of Botulinum Toxin A (Wocktox)?

Who should not undergo Botulinum Toxin A (Wocktox) treatment (Contraindications)?

What medical history should a doctor collate before Botulinum Toxin A treatment?

What are the possible side effects of Botulinum Toxin A?

How does Botulinum Toxin A work?

What is the onset of action and duration of Botulinum Toxin A treatment?

Is there a substitute for Botulinum Toxin A?

Will the patient's face look overdone or natural?

Does the patient need to be over 40 years to start Botulinum Toxin A injections?

How many injections will the patient require?

Do you have any clinical trials of Wocktox?

Are there any specific precautions for washing the face after a Wocktox procedure? Can swimming be done after receiving Botulinum Toxin A injection?

What is the LD50 test and why is LD50 testing important?

What are the different competitor brands of Wocktox available in the Market?

What are the USPs of Wocktox?

Explore frequently asked questions

  • Botulinum Toxin A is a prescription drug which is USFDA-approved for temporary improvement of appearance of moderate to severe glabellar frown lines, outer canthal lines (crow's feet), and forehead lines in adults.

  • The FDA has approved Botulinum Toxin A for four aesthetic indications:

  • Botulinum Toxin A is effective for temporary improvement of dynamic facial wrinkles, which are visible only with expressions. Static facial wrinkles, which are present even in the absence of expressions, are not recommended to be treated by Botulinum Toxin A. (HYA Fillers are the ideal choice).

  • Active ingredient: Botulinum Toxin Type A; Inactive ingredients: 1 ng Human Serum Albumin (HSA) and 0.5 ng Sucrose.

  • The Thin Film Formulation technique ensures the stability of Botulinum Toxin A as per Indian DCGI norms and global standards, hence ensures purity of the molecule.

    Due to its world-class lyophilisation technology and purification process, it creates a thin, transparent film on the vial's surface, which is not visible to the naked eye.

  • The diluent for reconstitution is 0.9% preservative-free normal saline solution. For 50 units, add 1.25 ml of diluent, and for 100 units, add 2.5 ml of diluent, resulting in 4 units of Botulinum Toxin A in 0.1 ml solution.

  • After reconstitution, Wocktox is stable for up to 14 days at a temperature of 2°C - 8°C. Botulinum Toxin A (before reconstitution) remains stable for 6 months when stored at 25° C.

    Also, under standard conditions, a fresh vial of Wocktox, if not reconstituted, can remain stable for 36 months at 2 °C - 8 °C.

  • Botulinum Toxin A can spread over 1 to 3 cm. Onabotulinum Toxin A (Wocktox) showed less spread compared to (Dysport) abobotulinum toxin A. (https://doi.org/10.1007/BF00941758).

  • Botulinum Toxin A treatment should not be administered to individuals:

    • Hypersensitivity/ Allergic to any of the ingredients

    • Local skin infection at the injection site

    • With defective neuromuscular transmission (e.g., Myasthenia gravis or Eaton-Lambert Syndrome)

    • ​During pregnancy or lactation (Category C)

  • Before Botulinum Toxin A injection, it's crucial to collate information on:

    • Allergies to any botulinum toxin product.

    • Previous side effects from botulinum toxin products.

    • Respiratory -Dysphagia/Breathlessness and deglutition/ swallowing problems.

    • Bleeding disorders/ H/O Blood thinners or recent surgeries in the last 1- 3 months.

    • Facial muscle weakness/ Bells Palsy or eyelid droop.

    • Concurrent medications, including prescription, non-prescription, vitamins, and herbal products.

  • Botulinum Toxin A may cause side effects such as:

    • Discomfort or pain at the injection site for 1-7 days

    • Fatigue, Drowsiness and/or headache

    • Temporary Dryness of mouth/ Dysphagia/ Breathlessness/ Difficult Deglutition

    • Eye problems like double vision/Diplopia or drooping eyelids

    • ​Rare Allergic reactions

  • Botulinum Toxin A inhibits the release of acetylcholine, a neurotransmitter responsible for nerve-to-muscle communication, at the neuro-muscular junction, hence it prevents muscle contraction & the muscle remains in the relaxed mode for a temporary period of time (12-16 weeks). Hence the dynamic wrinkles disappear temporarily to the naked eye.

  • The onset of action is typically 3-5 days with optimum results at 2-4 weeks results can last up to three to four months for dynamic (Crow’s feet) lateral canthal lines, with individual variation.

  • Botulinum Toxin A is a biologic product with unique characteristics, making it non-interchangeable with other products.

    Its potency and safety cannot be claimed by any other product.

  • Botulinum Toxin A treatment relies on the skill of the practitioner to achieve natural-looking results, especially when administered by a licensed and trained professional. It is directly proportional to the recommended dose to be injected. Dose modifying factors should be considered before injection. Hence it is always claimed that underdosing, especially to naïve patients gives long term satisfaction & avoids lost on follow-up.

  • Age is not the determining factor for Botulinum Toxin A treatment; rather, it depends on the severity of wrinkles and individual goals. As per the USFDA/DCGI guidelines, BONT A treatment can be recommended to all individuals above 18 years of age, if needed.

  • The number of injections required varies based on the patient's goals and the areas to be treated. A personalized treatment plan will be determined during consultation with a doctor.

    Patients might require the treatment every 3-6 months, depending on the goal settings and the recommended plan, on the sole discretion of the clinician.

  • Yes, a split-face study of Wocktox was conducted in comparison to an international innovator brand (Botox) at Cutis Academy Bangalore in collaboration with Dr. BS Chandrasekhar/ Dr. Chytra/ Dr. Madura/ Dr. Rajesh Lalchandani, published in JCAS peer reviewed journal. The study involved 50 patients with 3 dropouts at 8 weeks, for the 12-week study, hence 47 patients completed the 12-week study, which suggested the non-inferiority of Wocktox compared to the international innovator brand of BONT A, with less stinging sensation at the injection site with Wocktox.

  • It is advisable to refrain from swimming for at least 24-72 hours following Botulinum Toxin A injection to prevent potential irritation of injection sites by chlorinated water. Vigorous swimming movements may also disturb the injection and impact its effectiveness.

     

    Also washing the face with chlorinated tap water is not advisable for the first 24-72 hours, due to the presence of mutated strains of Atypical Mycobacteria, which might be resistant to chlorination & may cause the potential risk of injection site infection.

  • LD50 stands for lethal dose 50, which represents the amount of a substance that is lethal to half (50%) of the experimental animals exposed to it. LD50 testing is significant in determining the toxicity level of a substance. For instance, as per EP/BP guidelines the LD50 of Wocktox is 109.4%, while the innovator brand has an LD50 of 116.4%, suggesting that the potency of Wocktox is comparable to that of the international brand.

  • Competitor brands of Botulinum Toxin A include BOTOX®, DYSPORT®, XEOMIN®, Nabota®, Chinese Botulinum Toxin A (CBTX-A), Neuronox® & Botulax®.

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    The unique selling points (USPs) of Wocktox include:

FAQ

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